What the evidence actually says about peptides

Product Transference Study of Testagen™ TDS®-Testosterone

ClinicalTrials.gov

This study will assess the potential of Testagen® TDS-Testosterone to enable transfer of Testosterone to females coming in contact with skin to which Testagen® TDS-Testosterone has been applied and the potential of product to raise serum androgen levels in those women.

Mitophagy and Mitochondrial DNA Dynamics During Ramadan Dry Fasting vs 16:8 Time-Restricted Feeding

ClinicalTrials.gov

This study investigates how different types of fasting affect cell health, specifically focusing on how mitochondria (the energy-producing parts of cells) are cleared and renewed.

Serum β-hCG Combined with Traditional Tumor Markers Improves Detection Efficacy and Prognostic Prediction in Cholangiocarcinoma

Kongsintaweesuk S, Pongking T, Tunbenjasiri K, Tanasuka P, Roytrakul S, Onsurathum S, Pairojkul C, Intuyod K, Luvira V, Pinlaor S, Blair D, Pinlaor P. · International journal of molecular sciences

Au-IDE/LFA biosensor: an integrated sensing platform with lateral flow immunoassay for quantitative detection of hCG hormone using non-faradaic continuous FFT-admittance voltammetry

Behrooz N, Shemirani F, Faridi-Majidi R. · BMC biotechnology

The development of the novel Au-IDE/LFA (gold interdigitated electrode with lateral flow immunoassay) biosensor, an integrated electrochemical sensing platform with lateral flow immunoassay, for quantitative detection of hCG (human Chorionic Gonadotropin) hormone levels is successfully directed here.

Locally Advanced Invasive Mole in the Presence of Low Serum β-hCG: A Case Report

Azzahra DM, Harsono AB, Nurdiawan W, Nisa AS, Mulya EPS. · International journal of women's health

Background Invasive mole is one of the most common forms of gestational trophoblastic neoplasia (GTN), characterized by hydropic chorionic villi with trophoblastic proliferation invading the myometrium.

Technical note: Development of a UHPLC-MS/MS method for the analysis of hCG and IGF-I from dried blood spots: A preliminary study

Tespio G, Pelletti G, Pascali JP, Demey E, Limaj X, Vinh J. · Forensic science international

Two of the most used hormones in sport, included in the WADA list of banned molecules, are human chorionic gonadotropin (hCG) and insulin-like growth factor (IGF-I).

Association between urinary hCG trajectories and the risk of miscarriage in women undergoing embryo transfer: a prospective cohort study

Wang J, Wang X, Wang L, Zhang X, Zang P, Han W, Chen L, Wang Q, Li Y, Cai L. · Frontiers in endocrinology

Objective To investigate the association between the dynamic trajectories of urinary human chorionic gonadotropin (hCG) and the risk of early miscarriage after embryo transfer. Methods In this prospective cohort study conducted in Hebei Maternity Hospital, 207 women undergoing embryo transfer were enrolled.

Morphological differentiation of hyperchromatic crowded groups (HCG) in cervical cytology. Possible clinical significance

Villarreal Ramírez JC, Guaithero Rivas JE, Ramírez L, Peña Guillén J, de Méndez MT. · Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia

HCG groups (hyperchromatic crowded groups) are hyperchromatic cellular aggregates observed during routine screening for cancer and premalignant intraepithelial lesions in both negative and abnormal cervical cytology samples.

Methotrexate in relatively contraindicated ectopic pregnancies: who benefits from treatment?

Özüm G, Güraslan H, Kurtoğlu N, Deniz L. · Archives of gynecology and obstetrics

Objective This study aimed to evaluate the efficacy of methotrexate (MTX) therapy and identify clinical and laboratory predictors of treatment failure, particularly in relatively contraindicated cases.

Case Report: Primary hepatic carcinosarcoma with ectopic β-hCG secretion and a paraneoplastic leukemoid reaction mimicking gynecologic and hematologic disease

Wang P, Xu X, Zhang L. · Frontiers in oncology

Primary hepatic carcinosarcoma is an exceptionally rare and highly aggressive malignancy, and ectopic β-hCG production and paraneoplastic leukemoid reaction are both uncommon findings in solid tumors.

Analysis of factors that increase serum progesterone levels on the day of hCG administration in gonadotropin-releasing hormone antagonist cycles

Wang J, Liu X, Xue J, Zhang Y. · Frontiers in endocrinology

Objective To explore the factors associated with elevated serum progesterone (P) levels on the day of hCG administration in patients undergoing controlled ovarian stimulation using a gonadotropin-releasing hormone antagonist (GnRH-A) protocol.

Pre-synchronization with GnRH or hCG enhances fertility outcomes of heat synch protocol in Holstein dairy cows across parities: A pilot study

Navidifar P, Kaveh A, Hosseini SE, Keshtkar Zolghadr H, Simiyari R, Taghinasab S, Salehi MS, Kahyani A. · Veterinary and animal science

Efficient estrus synchronization is important for improving reproductive performance in dairy herds; however, variations in ovarian activity among cows of different parities may influence responses to synchronization protocols.

A Case of a Chronic Ectopic Pregnancy in a Patient With Negative Serum β-HCG

Yu S, Su X, Liu L, Wang X, Chen X. · Clinical case reports

Chronic ectopic pregnancy should be considered in women with adnexal masses and persistent abdominal pain, even when serum β-hCG is negative, to prevent delayed diagnosis. This article reports a case of ectopic pregnancy with negative serum β-hCG levels nearly 3 months after curettage.

Association of human chorionic gonadotropin and post-pregnancy persistent enhanced myometrial vascularity

Timor-Tritsch IE, Monteagudo A, Platt LD, Shwayder JM, Maymon R, Kedem MR, Jauniaux E. · Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

Objective To explore the role of circulating human chorionic gonadotropin (hCG) in the pathophysiology of enhanced myometrial vascularity (EMV) postpregnancy and the usefulness of determining hCG level in the clinical evaluation and management of this condition.

Acupuncture for Postoperative Gastric Emptying Delay

ClinicalTrials.gov

This multicenter clinical trial, conducted at Qilu Hospital of Shandong University and collaborating institutions, prospectively assesses the efficacy and safety of acupuncture for postoperative delayed gastric emptying.

Balancing the benefits and risks of GLP-1 receptor agonists: a clinical guide for shared decision-making

Moiz A, Peters TM, Tsoukas MA, Yu OHY, Filion KB, Eisenberg MJ. · EClinicalMedicine

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are now used widely to manage diabetes, obesity, and an expanding set of metabolic and cardiorenal conditions.

The use of GLP-1 receptor agonists and co-agonists in adults without diabetes: a systematic review and network meta-analysis protocol

Moiz A, Reynier P, Tsoukas MA, Yu OH, Peters TM, Eisenberg MJ, Filion KB. · Systematic reviews

Background Despite the increasing clinical use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs), head-to-head evidence across these agents remains limited.

Dysesthesia associated with GLP-1 agonist therapies: data-mining analysis and literature review

Laroche ML, Géniaux H, Jardou M. · European journal of clinical pharmacology

Purpose An increasing number of anecdotal reports on social media platforms and medical blogs describe dysesthesia, particularly burning skin sensations, in association with glucagon-like peptide-1 receptor (GLP-1R) agonists.

Do no harm: managing nausea and vomiting in GLP-1 based obesity therapies

Alhazmi A, le Roux CW. · Frontiers in endocrinology

Evolution of incretin-based therapies: From GLP-1 monotherapy to dual and triple agonists: A new era in metabolic therapy

Gupta M, Shukla J. · The Indian journal of medical research

Incretin-based therapies have revolutionised the management of metabolic disorders, transitioning from DPP-4 inhibitors to advanced GLP-1 receptor agonists (GLP-1RAs) and next-generation dual and triple agonists.

Incretin-Based Dual and Triple Agonists in Overweight or Obese Individuals: A Systematic Review and Meta-Analysis

Chan ZH, Omar AS, Gill K, Volucke G, Azhar MM, Haleem SM, Sia JE, Rahman OU, Ahmad M, Shahid N, Gardezi SA, Joseph KV, Behary Paray N, Zulfiqar E. · Cardiology in review

Incretin-based dual and triple agonists have emerged as effective options for obesity management, offering enhanced weight loss through multi-receptor agonism. However, data on their efficacy and safety remain limited.

A Study to Estimate Early Clinical Efficacy Signals of GLP-1 Agonist Administration in Conjunction With Levonorgestrel Intrauterine Device in Obese Patients With Endometrioid Intraepithelial Neoplasia

ClinicalTrials.gov

This study will explore the use of glucagon-like peptide 1 receptor agonist (GLP-1RA) used concurrently with levonorgestrel intrauterine device in patients with poor surgical candidacy for a hysterectomy or patients who are pursuing fertility sparing.

Incretin Therapies in Obesity-related HFpEF

ClinicalTrials.gov

The central hypothesis to be tested is that patients with obesity and heart failure with preserved ejection fraction (HFpEF) prescribed tirzepatide will demonstrate reductions in measured plasma volume.

Impact of tirzepatide on systemic arterial stiffness assessed by cardio-ankle vascular index in individuals with obesity complicated by type 2 diabetes: A retrospective cohort study in Japan

Nagayama D, Wakamatsu M, Watanabe Y, Ikeda M, Koshikawa Y, Horikawa O, Tsuji S, Shirai K, Saiki A. · Obesity pillars

Background Tirzepatide, a multi-agonist incretin agent that targets body weight and metabolic parameters, has stronger weight reduction and glycemic control effects than existing agents.

Comparative effectiveness of tirzepatide and DPP-4 inhibitors in type 2 diabetes with heart failure

Mortada I, Paul K, Chammany M, Abraham Y, Devulapally K, Lee AW, Mansour S, Chatila K, Boyars MC, Jehle D, Blackwell TA, Jneid H. · Diabetes & vascular disease research

While patients with type 2 diabetes mellitus (T2DM) and heart failure (HF) are frequently prescribed dipeptidyl peptidase-4 inhibitors (DPP-4is), emerging evidence suggests glucagon-like peptide-1 receptor agonists may offer improved outcomes.

Neuropsychiatric Outcomes With Tirzepatide, Semaglutide, and Other GLP-1 Receptor Agonists

Chen SC, Wang TJ, Chou CK, Lee C. · Diabetes, obesity & metabolism

Aims Neuropsychiatric safety concerns, including depression and suicidal ideation, have emerged during the expanding clinical use of incretin-based therapies for type 2 diabetes mellitus (T2DM) and obesity. However, whether risks differ across successive generations of incretin-based therapies remains uncertain.

Real-World Comparative Effectiveness of Tirzepatide and Semaglutide for Obesity: A Multicentered Study

Ghusn W, Fansa S, Tama E, Anazco D, Espinosa MA, Villamarin J, Cifuentes L, Gala K, Hurtado Andrade MD, Acosta A. · Mayo Clinic proceedings

Objective To compare the real-world weight loss effectiveness and safety of tirzepatide and semaglutide in patients treated for obesity, including those with prior obesity medication (OM) use.

Lower fall and femoral fracture risks with semaglutide and tirzepatide compared with DPP-4 inhibitors in older adults with type 2 diabetes

Chen HY, Wu JY, Chu YH, Chen TW, Huang CF. · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

This retrospective cohort study evaluated whether semaglutide and tirzepatide reduce the risk of falls and femoral fractures in older adults with type 2 diabetes and overweight or obesity. The findings showed significantly lower risks of both outcomes compared with DPP-4 inhibitors.

Starvation-Type Euglycemic Ketoacidosis After Unsupervised Tirzepatide Use in a Non-Obese, Non-Diabetic Woman

Abdelshafey EE, Sewify K, Almutairi A, Elmessery R, Alotaishan S, Al-Gindan YY, Ali Ahmad M, Gomaa W. · The American journal of case reports

BACKGROUND Tirzepatide is a dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist approved for type 2 diabetes and chronic weight management in adults meeting clinical criteria. Appetite suppression and gastrointestinal intolerance can markedly reduce intake.

Tirzepatide compared with semaglutide in obesity disease: a subpopulation analysis applying Japan Society for the Study of Obesity criteria in the global SURMOUNT-5 trial

Kitamoto T, Yoshino M, Shingaki T, Oura T, Gomez Valderas E, Dunn JP. · Current medical research and opinion

Objective To evaluate the efficacy and safety of tirzepatide versus semaglutide in individuals eligible for pharmacotherapy for obesity disease under Japan's national insurance criteria, where obesity is defined as body mass index (BMI) ≥25 kg/m 2 with excess adiposity.

Tirzepatide as a multi-organ integrator in metabolic diseases: a review of molecular mechanisms and clinical translation

Khan I, Meenakshi S, Abubakar M, Kumar N, Gaikwad VL, Rai A, Murti K. · Endocrine

Introduction Metabolic diseases, including type 2 diabetes mellitus (T2DM), obesity, dyslipidemia, Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), and obstructive sleep apnoea (OSA), are characterized by a complex and interconnected pathophysiological syndrome.

Real-World Effectiveness and Safety of Tirzepatide in Type 1 Diabetes and Obesity: Impact on Glycaemia, Weight, and Cardiometabolic Risk Markers

Berry SA, Goodman IR, McNally E, Elliott J, Iqbal A. · Diabetes, obesity & metabolism

Aims To evaluate the effectiveness and safety of tirzepatide on glycaemia, weight, and markers of cardiometabolic risk in people with type 1 diabetes and obesity.

Tirzepatide Regulates Pacemaker Function by Modulating cAMP and Calcium Dynamics in Human Sinoatrial Node Cells

Ren L, Belbachir N, Zhang H, Thai PN, Huang R, Zhu W, Wu X, Xie M, Gao J, Kim HY, Liu T, Sun J, Ghazizadeh Z, Navedo MF, Wu JC. · Circulation

Tirzepatide and risk of newly diagnosed aortic stenosis in patients with obesity: a multi-institutional real-world cohort study

Wu JY, Lee KW, Huang SC, Chang HY, Lin YM. · BMC cardiovascular disorders

Background Obesity is a major risk factor for the development of degenerative aortic stenosis (AS), yet no pharmacologic therapy has been proven to prevent AS onset.

Effects of Tirzepatide in Obesity-Related HFpEF by Sex: A Prespecified Secondary Analysis From the SUMMIT Trial

Borlaug BA, Zile MR, Kramer CM, Litwin SE, Ye W, Ou Y, Hurt K, Murakami M, Packer M, SUMMIT Trial Group. · JACC. Heart failure

Background The SUMMIT trial showed that the long-acting glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 receptor agonist tirzepatide decreased risk of cardiovascular death or worsening heart failure (HF) in patients with obesity-related heart failure with preserved ejection fraction (H…

ANP32E drives lung adenocarcinoma progression via GSK3β-mediated glycolytic reprogramming

Wang Z, Li Q, Ye Z, Wu X, Fang C, Jiang W, Zhu M. · Cell death & disease

Lung adenocarcinoma (LUAD), a leading cause of cancer mortality, involves incompletely understood epigenetic-metabolic crosstalk. We identified ANP32E as a key regulator through multi-omics (TCGA, scRNA-seq) and clinical analyses, finding its overexpression correlates with poor prognosis.

Targeting Leukopoiesis: Pharmacological and Biotechnological Strategies for the Treatment of Leukopenia

Baktybayeva L, Kaldybayeva AB, Sokolenko A, Tursynova B, Ten AY, Daulet G, Svambayev E, Thevis M, Yu VK, Tassibekov KS. · Biomedicines

Leukopenia remains a major clinical challenge associated with infectious diseases, oncological therapies, autoimmune disorders, and metabolic and iatrogenic conditions.

Zinc Coordination by Thymosin β4: Structural Determinants and Functional Implications

Lachowicz J, Congiu T, Salis A, Cesare Marincola F. · International journal of molecular sciences

A Prospective, Multicenter, Open-label, Single-arm Phase II Clinical Study Evaluating the Efficacy and Safety of Spatially Fractionated Radiotherapy Combined With the PraG Strategy for the Treatment of Soft Tissue Sarcoma

ClinicalTrials.gov

The primary objective of this clinical trial is to evaluate the efficacy and safety of spatially fractionated radiotherapy combined with the PraG strategy in the treatment of soft tissue sarcoma (STS). The main questions it aims to answer are: 1.

Thymosin-α1 for Recurrent Implantation Failure

ClinicalTrials.gov

Clinical trial evaluating the safety and efficacy of Thymosin-α1 (Tα1) as an adjunctive immunomodulatory therapy in women with unexplained recurrent implantation failure (RIF) undergoing IVF/ICSI cycles.

A Case Report of a Multisystemic Immune-Related Adverse Event Caused by Sintilimab in Combination With Thymosin Alpha-1

Li T, Wu BL, Yu CL, Jin LY. · Clinical case reports

To report a case of a nasopharyngeal carcinoma patient who developed multisystem immune-related adverse events (irAEs) after treatment with sintilimab (PD-1 inhibitor) in combination with thymosin alpha-1 (Tα1). The patient presents with high fever, rash, interstitial pulmonary edema, and multiple organ failure.

Thymosin Alpha-1 Restores Chemotherapy-Induced Antitumor Immunity by Chaperoning a MicroRNA Ligand of TLR7 in Dendritic Cells

Wei Y, Chen J, Zhang Y, Liu Y, Zhu F, Wang X, Zhou X, Wu C, Zhang W, Chen J, Zhang Y, Pan N, Chen K, Zheng S, Yan C, Liu L, Wang L. · Cancer research

Chemotherapy induces cancer cell apoptosis and the release of apoptotic bodies (ABs) that are poorly immunogenic or immunosuppressive, creating a major barrier to the success of co-administered or second-line immunotherapies.

Targeting Leukopoiesis: Pharmacological and Biotechnological Strategies for the Treatment of Leukopenia

Baktybayeva L, Kaldybayeva AB, Sokolenko A, Tursynova B, Ten AY, Daulet G, Svambayev E, Thevis M, Yu VK, Tassibekov KS. · Biomedicines

Leukopenia remains a major clinical challenge associated with infectious diseases, oncological therapies, autoimmune disorders, and metabolic and iatrogenic conditions.

Targeting Leukopoiesis: Pharmacological and Biotechnological Strategies for the Treatment of Leukopenia

Baktybayeva L, Kaldybayeva AB, Sokolenko A, Tursynova B, Ten AY, Daulet G, Svambayev E, Thevis M, Yu VK, Tassibekov KS. · Biomedicines

Leukopenia remains a major clinical challenge associated with infectious diseases, oncological therapies, autoimmune disorders, and metabolic and iatrogenic conditions.

Relationships of Anemia, Serum Iron, and Serum Copper in Hospitalized Alpacas (Vicugna pacos)

Kornblum M, Buchallik-Schregel J, Röhrig P, Polifka A, Ganter M, Wagener MG. · Biological trace element research

A large number of South American camelids (SAC) presented to a veterinary clinic are diagnosed with anemia.

Tesamorelin for Reduction of Liver Fat in Adults With Fatty Liver Disease (Mock Study)

ClinicalTrials.gov

This randomized, double-blind, placebo-controlled Phase II study evaluates whether daily subcutaneous tesamorelin (a growth hormone-releasing hormone analog) reduces liver fat in adults with fatty liver disease.

P-1231. A Phase 1 Open-label, Parallel-group, Single-dose Study to Evaluate the Pharmacokinetics and Safety of Obeldesivir in Participants with Normal Renal Function and Renal Impairment

Open Forum Infectious Diseases

Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians

Mayfield CK, Bolia IK, Feingold CL, Lin EH, Liu JN, Rick Hatch GF, Gamradt SC, Weber AE. · The American journal of sports medicine

Background Therapeutic peptides are short-chain amino acids that regulate cellular functions and facilitate biochemical processes. In recent years, there has been significant growth in the global market for therapeutic peptides and thus its popularity among patients.