What the evidence actually says about peptides

Product Transference Study of Testagen™ TDS®-Testosterone

ClinicalTrials.gov

This study will assess the potential of Testagen® TDS-Testosterone to enable transfer of Testosterone to females coming in contact with skin to which Testagen® TDS-Testosterone has been applied and the potential of product to raise serum androgen levels in those women.

SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial Cancer

ClinicalTrials.gov

SHAPE-ENDO is a single-center, open-label, pilot randomized clinical trial conducted at Hospital Universitari de Bellvitge in Barcelona, Spain.

Mitophagy and Mitochondrial DNA Dynamics During Ramadan Dry Fasting vs 16:8 Time-Restricted Feeding

ClinicalTrials.gov

This study investigates how different types of fasting affect cell health, specifically focusing on how mitochondria (the energy-producing parts of cells) are cleared and renewed.

Ectopic β-hCG-Expressing Hepatic Neoplasm with Cutaneous Metastasis in a Young Postpartum Woman: A Case Report and Literature Review

Zheng Y, Yang M, Xu W, Huang P. · International journal of women's health

This case report describes a rare presentation of intrahepatic cholangiocarcinoma (ICC) in a 33-year-old postpartum woman, with extensive systemic and cutaneous metastases as the initial clinical manifestations.

Pre-synchronization with GnRH or hCG enhances fertility outcomes of heat synch protocol in Holstein dairy cows across parities: A pilot study

Navidifar P, Kaveh A, Hosseini SE, Keshtkar Zolghadr H, Simiyari R, Taghinasab S, Salehi MS, Kahyani A. · Veterinary and animal science

Efficient estrus synchronization is important for improving reproductive performance in dairy herds; however, variations in ovarian activity among cows of different parities may influence responses to synchronization protocols.

Serum β-hCG Combined with Traditional Tumor Markers Improves Detection Efficacy and Prognostic Prediction in Cholangiocarcinoma

Kongsintaweesuk S, Pongking T, Tunbenjasiri K, Tanasuka P, Roytrakul S, Onsurathum S, Pairojkul C, Intuyod K, Luvira V, Pinlaor S, Blair D, Pinlaor P. · International journal of molecular sciences

Au-IDE/LFA biosensor: an integrated sensing platform with lateral flow immunoassay for quantitative detection of hCG hormone using non-faradaic continuous FFT-admittance voltammetry

Behrooz N, Shemirani F, Faridi-Majidi R. · BMC biotechnology

The development of the novel Au-IDE/LFA (gold interdigitated electrode with lateral flow immunoassay) biosensor, an integrated electrochemical sensing platform with lateral flow immunoassay, for quantitative detection of hCG (human Chorionic Gonadotropin) hormone levels is successfully directed here.

Locally Advanced Invasive Mole in the Presence of Low Serum β-hCG: A Case Report

Azzahra DM, Harsono AB, Nurdiawan W, Nisa AS, Mulya EPS. · International journal of women's health

Background Invasive mole is one of the most common forms of gestational trophoblastic neoplasia (GTN), characterized by hydropic chorionic villi with trophoblastic proliferation invading the myometrium.

Technical note: Development of a UHPLC-MS/MS method for the analysis of hCG and IGF-I from dried blood spots: A preliminary study

Tespio G, Pelletti G, Pascali JP, Demey E, Limaj X, Vinh J. · Forensic science international

Two of the most used hormones in sport, included in the WADA list of banned molecules, are human chorionic gonadotropin (hCG) and insulin-like growth factor (IGF-I).

Association between urinary hCG trajectories and the risk of miscarriage in women undergoing embryo transfer: a prospective cohort study

Wang J, Wang X, Wang L, Zhang X, Zang P, Han W, Chen L, Wang Q, Li Y, Cai L. · Frontiers in endocrinology

Objective To investigate the association between the dynamic trajectories of urinary human chorionic gonadotropin (hCG) and the risk of early miscarriage after embryo transfer. Methods In this prospective cohort study conducted in Hebei Maternity Hospital, 207 women undergoing embryo transfer were enrolled.

Morphological differentiation of hyperchromatic crowded groups (HCG) in cervical cytology. Possible clinical significance

Villarreal Ramírez JC, Guaithero Rivas JE, Ramírez L, Peña Guillén J, de Méndez MT. · Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia

HCG groups (hyperchromatic crowded groups) are hyperchromatic cellular aggregates observed during routine screening for cancer and premalignant intraepithelial lesions in both negative and abnormal cervical cytology samples.

Pre-synchronization with GnRH or hCG enhances fertility outcomes of heat synch protocol in Holstein dairy cows across parities: A pilot study

Navidifar P, kaveh A, Hosseini S, keshtkar zolghadr H, Simiyari R, Taghinasab S, Salehi M, Kahyani A. · Veterinary and animal science

Analysis of factors that increase serum progesterone levels on the day of hCG administration in gonadotropin-releasing hormone antagonist cycles

Wang J, Liu X, Xue J, Zhang Y. · Frontiers in endocrinology

Objective To explore the factors associated with elevated serum progesterone (P) levels on the day of hCG administration in patients undergoing controlled ovarian stimulation using a gonadotropin-releasing hormone antagonist (GnRH-A) protocol.

Association of human chorionic gonadotropin and post-pregnancy persistent enhanced myometrial vascularity

Timor-Tritsch IE, Monteagudo A, Platt LD, Shwayder JM, Maymon R, Kedem MR, Jauniaux E. · Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

Objective To explore the role of circulating human chorionic gonadotropin (hCG) in the pathophysiology of enhanced myometrial vascularity (EMV) postpregnancy and the usefulness of determining hCG level in the clinical evaluation and management of this condition.

A Case of a Chronic Ectopic Pregnancy in a Patient With Negative Serum β‐HCG

Yu S, Su X, Liu L, Wang X, Chen X. · Clinical case reports

Balancing the benefits and risks of GLP-1 receptor agonists: a clinical guide for shared decision-making

Moiz A, Peters TM, Tsoukas MA, Yu OHY, Filion KB, Eisenberg MJ. · EClinicalMedicine

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are now used widely to manage diabetes, obesity, and an expanding set of metabolic and cardiorenal conditions.

The use of GLP-1 receptor agonists and co-agonists in adults without diabetes: a systematic review and network meta-analysis protocol

Moiz A, Reynier P, Tsoukas MA, Yu OH, Peters TM, Eisenberg MJ, Filion KB. · Systematic reviews

Background Despite the increasing clinical use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs), head-to-head evidence across these agents remains limited.

Dysesthesia associated with GLP-1 agonist therapies: data-mining analysis and literature review

Laroche ML, Géniaux H, Jardou M. · European journal of clinical pharmacology

Purpose An increasing number of anecdotal reports on social media platforms and medical blogs describe dysesthesia, particularly burning skin sensations, in association with glucagon-like peptide-1 receptor (GLP-1R) agonists.

Do no harm: managing nausea and vomiting in GLP-1 based obesity therapies

Alhazmi A, le Roux CW. · Frontiers in endocrinology

Evolution of incretin-based therapies: From GLP-1 monotherapy to dual and triple agonists: A new era in metabolic therapy

Gupta M, Shukla J. · The Indian journal of medical research

Incretin-based therapies have revolutionised the management of metabolic disorders, transitioning from DPP-4 inhibitors to advanced GLP-1 receptor agonists (GLP-1RAs) and next-generation dual and triple agonists.

Incretin-Based Dual and Triple Agonists in Overweight or Obese Individuals: A Systematic Review and Meta-Analysis

Chan ZH, Omar AS, Gill K, Volucke G, Azhar MM, Haleem SM, Sia JE, Rahman OU, Ahmad M, Shahid N, Gardezi SA, Joseph KV, Behary Paray N, Zulfiqar E. · Cardiology in review

Incretin-based dual and triple agonists have emerged as effective options for obesity management, offering enhanced weight loss through multi-receptor agonism. However, data on their efficacy and safety remain limited.

Precision Obesity Medicine: Genetic Prediction of Response to GLP-1/GIP Agonists.

ClinicalTrials.gov

Obesity is a chronic multifactorial disease with a strong genetic component.

Real-world Effectiveness and Dosing Patterns of Tirzepatide in People With Obesity

ClinicalTrials.gov

Tirzepatide is one of the new medications for the treatment of obesity. In clinical research people treated with Tirzepatide have weight loss up to 21%. But there is only a little bit of research showing the effect of Tirzepatide in clinical practice.

A Study of Tirzepatide (LY3298176) in Adult Participants in India With Either Type 2 Diabetes Mellitus or Obesity

ClinicalTrials.gov

The main purpose of this study is to measure the safety and efficacy of tirzepatide in adult participants in India who have type 2 diabetes or who have obesity or overweight without type 2 diabetes. Participation in the study will last about 46 weeks.

Tirzepatide in Idiopathic Intracranial Hypertension Trial

ClinicalTrials.gov

This will be a randomized, double-blind, parallel, placebo-controlled trial of 60 participants.

Comparative Effectiveness of CagriSegma, Semaglutide, Cagrilintide and Tirzepatide in the Management of Overweight and Obesity: A Network Meta-Analysis of Randomized Clinical Trials

Hamarsheh S, Jaber AR, Abu-Khazneh O, Andonie CR, Majadleh S, Zahran A, Ayesh H. · Endocrinology, diabetes & metabolism

Background Obesity is a chronic, progressive disease affecting over 1 billion adults worldwide, linked to serious comorbidities, including diabetes, hypertension, and cardiovascular disease and associated with increased mortality. Achieving clinically meaningful weight loss is critical to reducing cardiometabolic risk.

Clinical Implications of Mounjaro (Tirzepatide) for Breast Cancer Detection and Management: A Narrative Review

Mady R, Tafazal H, Soliman H, Ramadan A, Hajaj M. · Cureus

Tirzepatide, marketed as Mounjaro, is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist that is widely used to treat type 2 diabetes and obesity.

Differential impact of pre-operative tirzepatide compared to glucagon-like-peptide-1 single receptor agonists on outcomes of spinal fusion surgery in obese patients

Sacks GI, Meydan Y, Lebens R, Mushlin HM. · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Study design Retrospective, propensity score-matched cohort study. Purpose To determine if outcomes following spinal fusion differ between obese patients prescribed Tirzepatide and single receptor glucagon-like-peptide-1 (srGLP-1) agonists preoperatively. Methods Data was collected from the TriNetX Research Network.

Tirzepatide Is Associated With Improved Metabolic Outcomes in People With Type 1 Diabetes and Overweight or Obesity: A Retrospective Cohort Study

Purcell AR, Longfield MSG, Rodrigo N, Glastras SJ. · Diabetes, obesity & metabolism

Aims To evaluate the effect of tirzepatide on body weight, glycaemic control, insulin requirements, continuous glucose monitoring (CGM) metrics and cardiorenal parameters in adults with Type 1 diabetes (T1D) and overweight or obesity.

Tirzepatide and the Cardiovascular Continuum: Metabolic, Cardiorenal and Heart Failure Evidence

Parlati AL, Martini L, Nardi E, Carluccio R, Parlati LE, Madaudo C, Perrone Filardi P. · Clinical Medicine Insights. Cardiology

Tirzepatide is a first-in-class, once-weekly dual GIP and GLP-1 receptor agonist approved for type 2 diabetes and obesity. Given the tight link between hyperglycemia, adiposity, and cardiovascular disease, tirzepatide has rapidly gained interest as a broader cardiometabolic intervention.

Weight-loss dynamics with tirzepatide versus semaglutide

Venkatakrishnan AJ, Murugadoss K, Soundararajan V. · PNAS nexus

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used for obesity and type 2 diabetes, yet substantial variability in weight-loss response remains poorly understood.

Efficacy of tirzepatide versus SGLT2 inhibitors in metabolic dysfunction-associated steatotic liver disease (MASLD): a multicenter propensity-matched real-world study

Khalil I, Sarker P, Nur N, Hossain MI, Khalid AA, Al-Badri SG, Akter MM, Das M, Rahman MT. · Hepatology international

Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent condition with significant cardiometabolic and hepatic risks.

Tirzepatide Regulates Pacemaker Function by Modulating cAMP and Calcium Dynamics in Human Sinoatrial Node Cells

Ren L, Belbachir N, Zhang H, Thai PN, Huang R, Zhu W, Wu X, Xie M, Gao J, Kim HY, Liu T, Sun J, Ghazizadeh Z, Navedo MF, Wu JC. · Circulation

Impact of tirzepatide on systemic arterial stiffness assessed by cardio-ankle vascular index in individuals with obesity complicated by type 2 diabetes: A retrospective cohort study in Japan

Nagayama D, Wakamatsu M, Watanabe Y, Ikeda M, Koshikawa Y, Horikawa O, Tsuji S, Shirai K, Saiki A. · Obesity pillars

Background Tirzepatide, a multi-agonist incretin agent that targets body weight and metabolic parameters, has stronger weight reduction and glycemic control effects than existing agents.

Starvation-Type Euglycemic Ketoacidosis After Unsupervised Tirzepatide Use in a Non-Obese, Non-Diabetic Woman

Abdelshafey EE, Sewify K, Almutairi A, Elmessery R, Alotaishan S, Al-Gindan YY, Ali Ahmad M, Gomaa W. · The American journal of case reports

BACKGROUND Tirzepatide is a dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist approved for type 2 diabetes and chronic weight management in adults meeting clinical criteria. Appetite suppression and gastrointestinal intolerance can markedly reduce intake.

Tirzepatide as a multi-organ integrator in metabolic diseases: a review of molecular mechanisms and clinical translation

Khan I, Meenakshi S, Abubakar M, Kumar N, Gaikwad VL, Rai A, Murti K. · Endocrine

Introduction Metabolic diseases, including type 2 diabetes mellitus (T2DM), obesity, dyslipidemia, Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), and obstructive sleep apnoea (OSA), are characterized by a complex and interconnected pathophysiological syndrome.

Real-World Comparative Effectiveness of Tirzepatide and Semaglutide for Obesity: A Multicentered Study

Ghusn W, Fansa S, Tama E, Anazco D, Espinosa MA, Villamarin J, Cifuentes L, Gala K, Hurtado Andrade MD, Acosta A. · Mayo Clinic proceedings

Objective To compare the real-world weight loss effectiveness and safety of tirzepatide and semaglutide in patients treated for obesity, including those with prior obesity medication (OM) use.

ANP32E drives lung adenocarcinoma progression via GSK3β-mediated glycolytic reprogramming

Wang Z, Li Q, Ye Z, Wu X, Fang C, Jiang W, Zhu M. · Cell death & disease

Lung adenocarcinoma (LUAD), a leading cause of cancer mortality, involves incompletely understood epigenetic-metabolic crosstalk. We identified ANP32E as a key regulator through multi-omics (TCGA, scRNA-seq) and clinical analyses, finding its overexpression correlates with poor prognosis.

Targeting Leukopoiesis: Pharmacological and Biotechnological Strategies for the Treatment of Leukopenia

Baktybayeva L, Kaldybayeva AB, Sokolenko A, Tursynova B, Ten AY, Daulet G, Svambayev E, Thevis M, Yu VK, Tassibekov KS. · Biomedicines

Leukopenia remains a major clinical challenge associated with infectious diseases, oncological therapies, autoimmune disorders, and metabolic and iatrogenic conditions.

Zinc Coordination by Thymosin β4: Structural Determinants and Functional Implications

Lachowicz J, Congiu T, Salis A, Cesare Marincola F. · International journal of molecular sciences

A Case Report of a Multisystemic Immune-Related Adverse Event Caused by Sintilimab in Combination With Thymosin Alpha-1

Li T, Wu BL, Yu CL, Jin LY. · Clinical case reports

To report a case of a nasopharyngeal carcinoma patient who developed multisystem immune-related adverse events (irAEs) after treatment with sintilimab (PD-1 inhibitor) in combination with thymosin alpha-1 (Tα1). The patient presents with high fever, rash, interstitial pulmonary edema, and multiple organ failure.

Thymosin Alpha-1 Restores Chemotherapy-Induced Antitumor Immunity by Chaperoning a MicroRNA Ligand of TLR7 in Dendritic Cells

Wei Y, Chen J, Zhang Y, Liu Y, Zhu F, Wang X, Zhou X, Wu C, Zhang W, Chen J, Zhang Y, Pan N, Chen K, Zheng S, Yan C, Liu L, Wang L. · Cancer research

Chemotherapy induces cancer cell apoptosis and the release of apoptotic bodies (ABs) that are poorly immunogenic or immunosuppressive, creating a major barrier to the success of co-administered or second-line immunotherapies.

Targeting Leukopoiesis: Pharmacological and Biotechnological Strategies for the Treatment of Leukopenia

Baktybayeva L, Kaldybayeva AB, Sokolenko A, Tursynova B, Ten AY, Daulet G, Svambayev E, Thevis M, Yu VK, Tassibekov KS. · Biomedicines

Leukopenia remains a major clinical challenge associated with infectious diseases, oncological therapies, autoimmune disorders, and metabolic and iatrogenic conditions.

Targeting Leukopoiesis: Pharmacological and Biotechnological Strategies for the Treatment of Leukopenia

Baktybayeva L, Kaldybayeva AB, Sokolenko A, Tursynova B, Ten AY, Daulet G, Svambayev E, Thevis M, Yu VK, Tassibekov KS. · Biomedicines

Leukopenia remains a major clinical challenge associated with infectious diseases, oncological therapies, autoimmune disorders, and metabolic and iatrogenic conditions.

Relationships of Anemia, Serum Iron, and Serum Copper in Hospitalized Alpacas (Vicugna pacos)

Kornblum M, Buchallik-Schregel J, Röhrig P, Polifka A, Ganter M, Wagener MG. · Biological trace element research

A large number of South American camelids (SAC) presented to a veterinary clinic are diagnosed with anemia.

Tesamorelin for Reduction of Liver Fat in Adults With Fatty Liver Disease (Mock Study)

ClinicalTrials.gov

This randomized, double-blind, placebo-controlled Phase II study evaluates whether daily subcutaneous tesamorelin (a growth hormone-releasing hormone analog) reduces liver fat in adults with fatty liver disease.

Obesity and Weight Management in HIV: Epidemiology, Complications, and Emerging Treatments

Pryke L, Koethe JR, Bailin S. · Current HIV/AIDS reports

Purpose of review People living with HIV (PLWH) on contemporary antiretroviral therapy experience high rates of overweight/obesity, which predisposes to cardiometabolic disease and multiple other conditions with negative health consequences in this aging population.

P-1231. A Phase 1 Open-label, Parallel-group, Single-dose Study to Evaluate the Pharmacokinetics and Safety of Obeldesivir in Participants with Normal Renal Function and Renal Impairment

Open Forum Infectious Diseases