PE-22-28
Also known as: PE 22-28
PE-22-28 is a 7-amino-acid synthetic analog of spadin, a peptide fragment (residues 22-28) of the 44-aa propeptide (PE) released during post-translational maturation of sortilin (the neurotensin receptor-3). It is studied in preclinical models as a fast-acting antidepressant that works by selectively blocking the TREK-1 two-pore potassium channel. There is no established use for hair growth — that is a separate compound and the two should not be confused.
Pricing for PE-22-28
Live vendor pricing, normalized to $/mg so sizes compare fairly — fused with each seller's Merit trust score and latest independent COA purity. Prices refresh daily.
Average price
$5.78/mg
range $3.46–$9.00/mg
Sellers
21
from $40.00
45-day trend
+3.7%
vs 45-day avg $/mg
17 of 21 sellers have a current price· 12 stale listings hidden (not seen in 7 days)
Top Merit pick
🇺🇸 Ion Peptide95✓ verified at source · just now
$4.90/mg -15.2% vs avg$49.00
10mg
99.8% purity 2 COAs- 🇺🇸 Peptide Plugs89
✓ verified at source · just now
$4.00/mg -30.8% vs avg$40.00
10mg
99.7% purity 1 COA - 🇺🇸 Peptidology89
✓ verified at source · just now
$5.00/mg -13.5% vs avg$49.99
10mg
- peptidetech.isUnscored
via Disclosed Labs · just now
$5.00/mg -13.5% vs avg$49.99
10mg
no purity - realpeptides.coUnscored
via Disclosed Labs · just now
$6.88/mg +19% vs avg$55.00
8mg
no purity
Prices observed from public storefronts (last 24h), normalized to $/mg. "Evidence" is Merit's 0–100 Merit Score, derived only from observable verification evidence (methodology on /about); "Purity" is the latest independent COA. Some buy links are affiliate links — Merit may earn a commission at no extra cost to you, and where a vendor offers one, the code shown gets you a discount at their checkout. Affiliate status never affects price data, ranking, or the Merit Score (full policy on /disclosure). Research use only.
COAs for PE-22-28
15 third-party tests across 7 vendors. Each card links to the full report.
For
PE-22-28
by Ion Peptide· batch PE228-05202026
For
PE-22-28
by Ion Peptide· batch PE228-05202026
For
Pe-22-28
by Real Peptides· batch Black Cap
For
PE-22-28
by Kimera Chems· batch KC-P28-YEL1
For
PE-22-28
by Peptidegurus· batch Jan 12nd 2026
For
PE-22-28
by Orbitrex Peptides· batch PE22101225
For
PE-22-28
by Peptidology· batch 1666
For
PE-22-28
by Ruo Bio· batch PE2001
For
PE-22-28
by Ascension Peptides· batch 41-06250728
For
PE-22-28
by Ascension Peptides· batch 41-06250728
For
PE-22-28
by Skye Peptides· batch PE25-08-001
For
PE-22-28
by Peptide Plugs· batch 129-01-SM
Purity not on file
For
PE-22-28
by Real Peptides
Purity not on file
For
PE-22-28
by Skye Peptides· batch PE25-10-001
Purity not on file
For
PE-22-28
by Ruo Bio
6 citations indexed for PE-22-28
rct · 2025
Effects of multivitamin combined with magnesium sulfate versus magnesium sulfate alone on hemodynamics, coagulation, and maternal-infant outcomes in preeclampsia: a randomized controlled study
Objective To explore the effects of multivitamin combined with magnesium sulfate on placental hemodynamics, coagulation function, and maternal and infant outcomes in preeclampsia patients.
review · 2023
Interventional Mental Health: A Transdisciplinary Approach to Novel Psychiatric Care Delivery
Mental health disorders are among the most common health conditions in the United States. Traditional clinical treatments rely on psychiatric counseling and, in many cases, prescription medications.
review · 2020
Enabling pregnant women and their physicians to make informed medication decisions using artificial intelligence
The role of artificial intelligence (AI) in healthcare for pregnant women. To assess the role of AI in women's health, discover gaps, and discuss the future of AI in maternal health. A systematic review of English articles using EMBASE, PubMed, and SCOPUS. Search terms included pregnancy and AI.
Study · 2020
Sex-specific and age-related seasonal variations regarding incidence and in-hospital mortality of pulmonary embolism in Germany
Background Studies have reported seasonal variations regarding the incidence and the short-term mortality of pulmonary embolism (PE). The aim of this study was to identify sex-specific and age-related differences in seasonal patterns regarding hospitalisations and mortality of PE patients.
review · 2019
Role of TREK-1 in Health and Disease, Focus on the Central Nervous System
TREK-1 is the most studied background K 2P channel. Its main role is to control cell excitability and maintain the membrane potential below the threshold of depolarization.
animal · 2017
Shortened Spadin Analogs Display Better TREK-1 Inhibition, <i>In Vivo</i> Stability and Antidepressant Activity
Depression is a devastating mental disorder that affects 20% of the population worldwide. Despite their proven efficacy, antidepressants present a delayed onset of action and serious adverse effects. Seven years ago, we described spadin (PE 12-28) as a promising endogenous peptide with antidepressant activity.