MOTS-c
Also known as: Mitochondrial Open reading frame of the Twelve S rRNA type-c
MOTS-c is an investigational mitochondrial-derived peptide studied preclinically for metabolic regulation. It is research-only and not FDA-approved; the CB4211 analog program (CohBar) was discontinued in 2023.
Pricing for MOTS-c
Live vendor pricing, normalized to $/mg so sizes compare fairly — fused with each seller's Merit trust score and latest independent COA purity. Prices refresh daily.
Average price
$4.39/mg
range $0.00–$11.60/mg
Sellers
89
from $0.00
45-day trend
-13.9%
vs 45-day avg $/mg
82 of 89 sellers have a current price· 50 stale listings hidden (not seen in 7 days)
Top Merit pick
🇺🇸 Peptide Partners99via Disclosed Labs · just now
$2.00/mg -54.4% vs avg$800
400mg
- 🇺🇸 Glacier Aminos99
✓ verified at source · just now
$2.30/mg -47.6% vs avg$45.99
20mg
- 🇺🇸 BioLongevity Labs96
via Disclosed Labs · just now
$11.00/mg +150.7% vs avg$110
10mg
- 🇺🇸 Reta One Labs95
via Disclosed Labs · just now
$1.80/mg -59% vs avg$72.00
40mg
- 🇺🇸 Licensed Peptides95
✓ verified at source · just now
$1.92/mg -56.1% vs avg$76.99
40mg
- 🇺🇸 Orbitrex Peptides95
via Disclosed Labs · just now
$3.50/mg -20.2% vs avg$140
40mg
99.0% purity 5 COAs - 🇺🇸 Prime Peptides95
via Disclosed Labs · just now
$5.50/mg +25.4% vs avg$55.00
10mg
- 🇺🇸 Mile High Compounds94
✓ verified at source · just now
$1.25/mg -71.5% vs avg$49.99
40mg
99.7% purity 2 COAs - 🇺🇸 Forge Performance Co.94
via Disclosed Labs · just now
$3.50/mg -20.2% vs avg$70.00
20mg
- 🇺🇸 Hydro Research Peptides91
via Disclosed Labs · just now
$7.00/mg +59.6% vs avg$35.00
5mg
- 🇺🇸 Peptidology89
✓ verified at source · just now
$1.23/mg -72.1% vs avg$49.00
40mg
- 🇺🇸 Peptide Plugs89
✓ verified at source · just now
$2.50/mg -43% vs avg$100
40mg
- 🇺🇸 Verified Peptides86
via Disclosed Labs · just now
$3.85/mg -12.2% vs avg$77.00
20mg
- 🇺🇸 Simple Peptide85
via Disclosed Labs · just now
$2.85/mg -35% vs avg$114
40mg
- 🇺🇸 EZ Peptides85
✓ verified at source · just now
$5.40/mg +23.1% vs avg$54.00
10mg
99.7% purity 4 COAs - 🇺🇸 Ascension Peptides84
via Disclosed Labs · just now
$4.90/mg +11.7% vs avg$49.00
10mg
no purity - Peptide Supply Co.83
via Disclosed Labs · just now
$1.25/mg -71.5% vs avg$500
400mg
99.7% purity 6 COAs - 🇨🇳 Reta Peptide83
✓ verified at source · just now
$6.50/mg +48.2% vs avg$65.00
10mg
99.4% purity 1 COA - 🇺🇸 MedGe Peptides82
✓ verified at source · just now
$6.50/mg +48.2% vs avg$65.00
10mg
- 🇺🇸 Blank Peptides81
✓ verified at source · just now
$6.50/mg +48.2% vs avg$65.00
10mg
99.5% purity 2 COAs - 🇺🇸 OROS Research79
via Disclosed Labs · just now
$5.00/mg +14% vs avg$99.99
20mg
99.0% purity 3 COAs - 🇺🇸 Texpeptide65
✓ verified at source · just now
$4.50/mg +2.6% vs avg$45.00
10mg
no purity - 🇨🇳 Qing Li Peptide64
✓ verified at source · just now
$0.00/mg -100% vs avg$0.00
10mg
99.8% purity 1 COA - 🇺🇸 Certified Peptides62
✓ verified at source · just now
$5.80/mg +32.2% vs avg$58.00
10mg
no purity 3 COAs - 🇭🇰 zztai Peptide Ltd43
✓ verified at source · just now
$5.00/mg +14% vs avg$200
40mg
no purity - 🇺🇸 NG PeptideUnscored
via Disclosed Labs · just now
$2.00/mg -54.4% vs avg$80.00
40mg
no purity - volterasciences.comUnscored
via Disclosed Labs · just now
$2.50/mg -43% vs avg$99.99
40mg
no purity - 🇺🇸 Alpha PeptidesUnscored
via Disclosed Labs · just now
$2.75/mg -37.2% vs avg$27.55
10mg
no purity - peptidetech.isUnscored
via Disclosed Labs · just now
$4.50/mg +2.6% vs avg$44.99
10mg
no purity - 🇺🇸 Kimera ChemsUnscored
via Disclosed Labs · just now
$5.00/mg +14% vs avg$49.99
10mg
no purity - optimasupply.isUnscored
via Disclosed Labs · just now
$6.50/mg +48.2% vs avg$65.00
10mg
no purity - realpeptides.coUnscored
via Disclosed Labs · just now
$7.00/mg +59.6% vs avg$280
40mg
no purity
Prices observed from public storefronts (last 24h), normalized to $/mg. "Evidence" is Merit's 0–100 Merit Score, derived only from observable verification evidence (methodology on /about); "Purity" is the latest independent COA. Some buy links are affiliate links — Merit may earn a commission at no extra cost to you, and where a vendor offers one, the code shown gets you a discount at their checkout. Affiliate status never affects price data, ranking, or the Merit Score (full policy on /disclosure). Research use only.
COAs for MOTS-c
270 third-party tests across 36 vendors. Each card links to the full report.
For
MOTS-C
by Peptide Plugs· batch 149-01-DK
For
MOTS-C
by NG Peptide· batch MS40-08
For
MOTS-c
by Real Peptides· batch RP062326MC
For
MOTS-C
by Sunrise Bioresearch· batch MTC10MAY26-02
For
MOTS-C
by Sunrise Bioresearch· batch MTC10MAY26-02
For
MOTS-C
by Apexx Biolabs· batch Light Purple Cap-1
For
MOTS-c
by Real Peptides· batch BATCH-0322
For
MOTS-C
by Ion Peptide· batch MC40-06032026
For
MOTS-C
by Peptide Plugs· batch 127-02-DK
For
MOTS-C
by Peptide Partners· batch SPL-4096
For
MOTS-C
by Voltera Sciences· batch MS40.05.28.26
For
MOTS-C
by Verified Peptides· batch M005261320L
For
MOTS-C
by Crush Research· batch CRMTS-40-2605-2
For
MOTS-C
by Crush Research· batch CR-MOTS20-2605-1
For
MOTS-C
by Crush Research· batch CRMTS-40-2605-1
For
MOTS-C
by Crush Research· batch CRMTS-10-2605-1
For
MOTS-c
by Reta One Labs· batch MTS100626
For
MOTS-C
by Nox Amino· batch NA-MS0226-01
For
MOTS-c
by Blank Peptides· batch B-7058391-P
For
MOTS-C
by NG Peptide· batch MTS40-07
For
MOTS-c
by Peptide Supply Co.· batch MC1005192026
For
MOTS-c
by Ion Peptide· batch MC10-05072026
For
MOTS-c
by Prime Peptides· batch 4052026MO
For
MOTS-c
by BioLongevity Labs· batch 18-3-46154
23 citations indexed for MOTS-c
cohort · 2027
Mitophagy and Mitochondrial DNA Dynamics During Ramadan Dry Fasting vs 16:8 Time-Restricted Feeding
This study investigates how different types of fasting affect cell health, specifically focusing on how mitochondria (the energy-producing parts of cells) are cleared and renewed.
Study · 2026
Are serum MOTS-c levels and MOTS-c m.1382A>C polymorphism related to polycystic ovary syndrome?
Objective MOTS-c is a mitochondria-derived peptide associated with reduced insulin resistance and obesity. The m.1382A>C polymorphism of the MOTS-c gene is linked to an increased risk of type 2 diabetes in men.
animal · 2026
MOTS-c partially protects against skeletal muscle deterioration in C26 cachexia
Background Cancer cachexia is a multifactorial metabolic syndrome marked by progressive skeletal muscle loss, reduced function, and increased mortality. Mitochondrial dysfunction is a key driver of this phenotype.
Study · 2026
Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction
Background: Atrial fibrillation (AF) is a common clinical arrhythmia associated with mitochondrial dysfunction, oxidative stress, and atrial fibrosis. Mitochondrial-derived peptides (MDPs), including humanin (HN) and MOTS-c, exhibit cytoprotective properties, but their role in AF remains largely unknown.
Study · 2026
Mitochondrial peptide MOTS-c suppresses systemic and cardiac inflammasome activation in a diabetic rat model
Type 2 diabetes mellitus (T2DM) is associated with chronic systemic and cardiac inflammation, contributing to the development of diabetic cardiomyopathy.
review · 2026
MOTS-c: How a secreted mitochondrial microprotein may become a potential treatment for inflammatory lung diseases
Background MOTS-c is a mitochondrial-derived microprotein (mitokine) encoded within the 12 S rRNA gene that exerts intracrine, paracrine, and endocrine effects across multiple tissues.