Matrixyl
Also known as: Palmitoyl Pentapeptide-4, Palmitoyl Pentapeptide-3, Pal-KTTKS, Palmitoyl-Lys-Thr-Thr-Lys-Ser
Matrixyl is the trade name for palmitoyl pentapeptide-4 (Pal-KTTKS), a topically applied cosmetic peptide consisting of the matrikine pentapeptide KTTKS — a subfragment of type I procollagen — conjugated to palmitic acid to improve skin penetration. It is marketed to stimulate fibroblast production of collagen, elastin, and other extracellular-matrix components, thereby reducing the appearance of fine lines and wrinkles. In the U.S. it is regulated as a cosmetic ingredient and is NOT an FDA-approved drug.
Common research uses
Pricing for Matrixyl
Live vendor pricing, normalized to $/mg so sizes compare fairly — fused with each seller's Merit trust score and latest independent COA purity. Prices refresh daily.
Average price
$12.90/mg
range $12.90–$12.90/mg
Sellers
1
from $129
45-day trend
+11.9%
vs 45-day avg $/mg
1 of 1 sellers have a current price
- 🇺🇸 Ion Peptide95
✓ verified at source · just now
$12.90/mg 0% vs avg$129
10mg
99.7% purity 2 COAs
Prices observed from public storefronts (last 24h), normalized to $/mg. "Evidence" is Merit's 0–100 Merit Score, derived only from observable verification evidence (methodology on /about); "Purity" is the latest independent COA. Some buy links are affiliate links — Merit may earn a commission at no extra cost to you, and where a vendor offers one, the code shown gets you a discount at their checkout. Affiliate status never affects price data, ranking, or the Merit Score (full policy on /disclosure). Research use only.
COAs for Matrixyl
2 third-party tests across 1 vendor. Each card links to the full report.
12 citations indexed for Matrixyl
review · 2026
Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications, and Future Perspectives
Therapeutic peptides are short chains of amino acids used to treat metabolic and endocrine conditions such as obesity and type 2 diabetes.
Study · 2026
Nanostructure and Collagen-Stimulating Activity of Cationic Pentapeptide Lipopeptides
The self-assembly in aqueous solutions, cytocompatibility, and collagen production of lipopeptide C 16 -KTTKS and a variant with arginine substitution for lysine, C 16 -RTTRS, are investigated. C 16 -KTTKS is known commercially as Matrixyl and is used in cosmetic formulations as it can stimulate collagen production.
review · 2026
Oral and topical peptides for skin aging: systematic review and meta-analysis of randomized controlled trials
Introduction Skin aging manifests as wrinkles, reduced elasticity, and roughness due to intrinsic and extrinsic factors. Peptide-based therapies enhance collagen synthesis and extracellular matrix integrity.
review · 2026
Integrative Dermatology for Longevity: The Synergy of Topical and Internal Approaches
Skin aging reflects both intrinsic biological decline and extrinsic influences collectively known as the skin exposome, including ultraviolet (UV) radiation, air pollution, psychosocial stress, fatigue, sleep disruption, and suboptimal lifestyle behaviors.
Study · 2025
Synergistic Effects of Injectable Platelet-Rich Fibrin and Bioactive Peptides on Dermal Fibroblast Viability and Extracellular Matrix Gene Expression: An In Vitro Study
Facial aging is a multifactorial process involving changes in bone, fat compartments, ligaments, muscles, and skin. Collagen biostimulators, including synthetic agents and autologous platelet concentrates, have gained attention for facial rejuvenation.
Study · 2025
Natural dual inhibitor isorhamnetin-3-O-neohespeidoside targets tyrosinase and MC1R for skin pigmentation management
Skin pigmentation disorders involve complex biological regulation, with tyrosinase (TYR) and melanocortin 1 receptor (MC1R) serving as key therapeutic targets.