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Immune Modulator

Epithalon

Also known as: Epitalon (AEDG, synthetic analog of Epithalamin)

Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Khavinson as an analog of the bovine pineal extract Epithalamin. It is a research-only bioregulator — not FDA-approved — investigated for claimed telomerase activation and circadian/melatonin effects, with evidence limited primarily to Khavinson-group studies.

Real-time market data

Pricing for Epithalon

Live vendor pricing, normalized to $/mg so sizes compare fairly — fused with each seller's Merit trust score and latest independent COA purity. Prices refresh daily.

Average price

$3.49/mg

range $0.90–$15.00/mg

Sellers

75

from $0.00

45-day trend

-11.1%

vs 45-day avg $/mg

65 of 75 sellers have a current price· 45 stale listings hidden (not seen in 7 days)

Prices observed from public storefronts (last 24h), normalized to $/mg. "Evidence" is Merit's 0–100 Merit Score, derived only from observable verification evidence (methodology on /about); "Purity" is the latest independent COA. Some buy links are affiliate links — Merit may earn a commission at no extra cost to you, and where a vendor offers one, the code shown gets you a discount at their checkout. Affiliate status never affects price data, ranking, or the Merit Score (full policy on /disclosure). Research use only.

Independent evidence

COAs for Epithalon

110 third-party tests across 26 vendors. Each card links to the full report.

All 110 COAs for Epithalon →
Measured purity 86.0%–99.9% across 70 COAs
Measured purity over time
✓ Vendor-published
99.71 %
Jul 2026
Freedom Diagnostics Moderate

For

Epithalon

by Ion Peptide· batch EP50-02032026

COA on file
✓ Vendor-published
99.86 %
Jun 2026
Freedom Diagnostics Moderate

For

Epithalon

by Ion Peptide· batch ET50-06242026

COA on file
Aggregated · 3rd-party listing
99.86 %
Jun 2026
Freedom Diagnostics Moderate

For

Epithalon

by Ion Peptide· batch ET50-06242026

Aggregated · 3rd-party listing
99.33 %
May 2026
Freedom Diagnostics Moderate

For

Epithalon

by Profound Aminos· batch Blue Cap

Aggregated · 3rd-party listing
99.00 %
May 2026
Ethos Analytics Strong · HPLC

For

Epithalon

by OROS Research· batch OR-LPEPI10-526-B2

Aggregated · 3rd-party listing
99.80 %
May 2026
ZYNTRO Analytical Lab Solutions

For

Epithalon

by Profound Aminos

✓ Vendor-published
99.86 %
May 2026
Kovera Labs

For

Epithalon

by Peptide Partners· batch ET202604

COA on file
Aggregated · 3rd-party listing
99.08 %
May 2026
ILS Labs Strong · HPLC

For

Epithalon

by Crush Research· batch CRET-50-0212-1

Aggregated · 3rd-party listing
99.06 %
May 2026
ILS Labs Strong

For

Epithalon

by Ion Peptide· batch ET50-05042026

Aggregated · 3rd-party listing
99.78 %
May 2026
MDx BioAnalytical Laboratory Strong

For

Epithalon

by BioLongevity Labs· batch 9-3-46146

Aggregated · 3rd-party listing
99.66 %
May 2026
Freedom Diagnostics Moderate

For

Epithalon

by Real Peptides· batch Orange Cap

Aggregated · 3rd-party listing
99.60 %
Apr 2026
Janoshik Analytical Limited · HPLC

For

Epithalon

by Verified Peptides· batch cmp4wgbkb004jx7rxdpeilkwp

Aggregated · 3rd-party listing
99.60 %
Apr 2026
Janoshik Analytical Limited · HPLC

For

Epithalon

by Verified Peptides· batch cmp4wgbn6004kx7rx72c6lhyu

Aggregated · 3rd-party listing
99.60 %
Apr 2026
Janoshik Analytical Limited · HPLC

For

Epithalon

by Verified Peptides· batch cmp4wgbpl004lx7rxfa45zj6b

Aggregated · 3rd-party listing
99.74 %
Apr 2026
Freedom Diagnostics Moderate · HPLC

For

Epithalon

by Peptide Plugs· batch 115-B-DK

Aggregated · 3rd-party listing
99.62 %
Apr 2026
Janoshik Analytical Limited · HPLC

For

Epithalon

by Qihang Peptide· batch 4

Aggregated · 3rd-party listing
99.00 %
Apr 2026
Ethos Analytics Strong · HPLC

For

Epithalon

by OROS Research· batch OR-LPEPI10-326-B2

Aggregated · 3rd-party listing
99.93 %
Apr 2026
Kovera Labs · HPLC

For

Epithalon

by Glacier Aminos· batch EPI10GA-02

Aggregated · 3rd-party listing
99.69 %
Apr 2026
Biogenica Labs · HPLC

For

Epithalon

by Amino Club· batch EPI0001

Aggregated · 3rd-party listing
99.59 %
Apr 2026
Vanguard Laboratory Strong

For

Epithalon

by Peptidology· batch 1673

Aggregated · 3rd-party listing
99.40 %
Mar 2026
Analytical Formulations, Inc.

For

Epithalon

by Ion Peptide· batch ET10-03102026

✓ Vendor-published
99.40 %
Feb 2026
Analytical Formulations, Inc.

For

Epithalon 10mg

by Ion Peptide· batch ET10-02232026

COA on file
Aggregated · 3rd-party listing
99.35 %
Feb 2026
Freedom Diagnostics Moderate · HPLC

For

Epithalon

by Crush Research· batch CR-ET40-0217-1

Aggregated · 3rd-party listing
99.40 %
Feb 2026
Analytical Formulations, Inc.

For

Epithalon

by Ion Peptide· batch ET10-02232026

Research depth

12 citations indexed for Epithalon

All research on Epithalon →

review · 2026

Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions

Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, grounded in their ability to modulate molecular signaling networks central to cellular medicine.

review · 2026

Therapeutic peptides in gerontology: mechanisms and applications for healthy aging

Background Peptide therapeutics represent an emerging frontier in gerontological medicine, targeting fundamental hallmarks of aging including metabolic dysfunction, telomere attrition, tissue repair impairment, and hormonal decline.

meta-analysis · 2026

Efficacy and Safety of Melatonin in Migraine Prophylaxis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Background Migraine is a chronic, disabling brain disorder. Melatonin, a circadian regulator with anti-inflammatory and antinociceptive actions, has been proposed for migraine prevention. We evaluated the efficacy and safety of melatonin for prophylaxis.

review · 2025

Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties

Epitalon, also known as Epithalon or Epithalone, is a tetrapeptide, Ala-Glu-Asp-Gly (AEDG), which was synthesized based on the amino acids composition of Epithalamin, a bovine pineal gland extract, prior to its discovery in pineal gland polypeptide complex solution.

Study · 2025

Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity

Epitalon, a naturally occurring tetrapeptide, is known for its anti-aging effects on mammalian cells. This happens through the induction of telomerase enzyme activity, resulting in the extension of telomere length. A strong link exists between telomere length and aging-related diseases.

review · 2024

[Peptidergic regulation of expression of cellular aging marker proteins in buccal epithelium.]

The review presents the results of long-term research conducted by the staff of the Saint-Petersburg Institute of Bioregulation and Gerontology, dedicated to the study of the biological activity of peptide bioregulators at all levels of a living organism's organization.