Dermorphin
Also known as: DRM
Naturally occurring heptapeptide first isolated from the skin of South American Phyllomedusa frogs. It is a highly selective, potent agonist of the mu-opioid receptor (MOR), reported to be roughly 30-40 times more potent than morphine on a molar basis, with low affinity for delta-opioid receptors. Its activity depends on the unusual D-alanine residue at position 2 (one of the few vertebrate peptides containing a D-amino acid) and C-terminal amidation, which confer resistance to peptidases. Dermorphin is not an approved human drug and has no legitimate clinical or nootropic use; it is studied as a pharmacological probe of opioid signaling.
Common research uses
Pricing for Dermorphin
Live vendor pricing, normalized to $/mg so sizes compare fairly — fused with each seller's Merit trust score and latest independent COA purity. Prices refresh daily.
Average price
$7.20/mg
range $7.20–$7.20/mg
Sellers
1
from $36.00
45-day trend
0%
vs 45-day avg $/mg
1 of 1 sellers have a current price
- 🇭🇰 zztai Peptide Ltd43
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$7.20/mg 0% vs avg$36.00
5mg
no purity
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COAs for Dermorphin
1 third-party test across 1 vendor. Each card links to the full report.
12 citations indexed for Dermorphin
animal · 2026
Dermorphin blocks apneic response to intravenous bolus injection of fentanyl
Background Sudden death induced by intravenous bolus (IVb) injection of overdose fentanyl is the major cause of overdose opioid-induced deaths; however, the relevant countermeasure is lacking.
Study · 2026
Nanoassembly-enabled aqueous solid-phase peptide synthesis (ASPPS): a practical DMF-free approach based on the Fmoc strategy
The urgent need for sustainable peptide manufacturing has accelerated efforts to replace conventional N , N -dimethylformamide (DMF)-based solid-phase peptide synthesis (SPPS) with greener alternatives.
Study · 2026
Differential opioid receptor expression and biochemical coupling profiles on glia
The opioid receptor family comprises classical; MOP (mu/µ), KOP (kappa/k), DOP(delta/δ) receptors along with non-classical Nociceptin/Orphanin FQ (N/OFQ) peptide receptor (NOP). Expression on glial cells is controversial where there is a role for glia and opioids in pain processing and immunomodulation.
Study · 2026
Receptor Binding, Functional Activity, and Cell Viability Assessment of Novel Marine-Based Hybrid Peptides from <i>Raja porosa</i>
The hybrid approach remains a compelling strategy for designing molecules that combine enhanced biological activity with a favorable safety profile. Marine peptides, in particular, have attracted significant attention due to their well-documented broad spectrum of biological activities.
animal · 2025
The Neurotropic Activity of Novel Dermorphin Analogs Active at Systemic and Noninvasive Administration
The neuropeptide's multifaceted involvement in various components of neural homeostasis impacts pain and behavioral regulation. One of the highly potent neuropeptides is dermorphin, extracted from the skin of the Amazon frog ( Phyllomedusa sauvagei ).
animal · 2025
Respiratory and Cardiovascular Activity of LENART01, an Analgesic Dermorphin-Ranatensin Hybrid Peptide, in Anesthetized Rats
Opioids are among the most effective drugs for treating moderate to severe pain. Unfortunately, opioid use, even short-term, can lead to addiction, tolerance, overdose, and respiratory depression.