For research use only. Not for human consumption. Not medical advice — consult a licensed clinician.

Immune Modulator

Bronchogen

Also known as: AEDL, Ala-Glu-Asp-Leu, T-33, lung peptide bioregulator

Research use only · not FDA-approved research only

Synthetic short-chain tetrapeptide bioregulator (Ala-Glu-Asp-Leu, AEDL) from the Khavinson family of tissue-specific peptides, developed by Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology and designed from amino-acid analysis of bronchial-mucosa peptide extracts. It is proposed to act epigenetically, penetrating cells and binding DNA to modulate tissue-specific gene expression and protein synthesis in bronchial epithelium and lung tissue. Evidence is almost entirely preclinical and from Russian-language sources; no controlled human clinical trials meeting international standards have been published. It is not FDA-approved or FDA-evaluated and is sold as a grey-market research compound.

Common research uses

respiratory/bronchial tissue research (research only)investigational respiratory-aging and lung-function studies (preclinical)
Real-time market data

Pricing for Bronchogen

Live vendor pricing, normalized to $/mg so sizes compare fairly — fused with each seller's Merit trust score and latest independent COA purity. Prices refresh daily.

Average price

$3.67/mg

range $2.00–$5.25/mg

Sellers

4

from $39.99

45-day trend

+4.4%

vs 45-day avg $/mg

4 of 4 sellers have a current price· 1 stale listing hidden (not seen in 7 days)

Prices observed from public storefronts (last 24h), normalized to $/mg. "Evidence" is Merit's 0–100 Merit Score, derived only from observable verification evidence (methodology on /about); "Purity" is the latest independent COA. Some buy links are affiliate links — Merit may earn a commission at no extra cost to you, and where a vendor offers one, the code shown gets you a discount at their checkout. Affiliate status never affects price data, ranking, or the Merit Score (full policy on /disclosure). Research use only.

Research depth

13 citations indexed for Bronchogen

All research on Bronchogen →

review · 2022

Transport of Biologically Active Ultrashort Peptides Using POT and LAT Carriers

Ultrashort peptides (USPs), consisting of 2-7 amino-acid residues, are a group of signaling molecules that regulate gene expression and protein synthesis under normal conditions in various diseases and ageing. USPs serve as a basis for the development of drugs with a targeted mechanism of action.

review · 2020

Peptides: Prospects for Use in the Treatment of COVID-19

There is a vast practice of using antimalarial drugs, RAS inhibitors, serine protease inhibitors, inhibitors of the RNA-dependent RNA polymerase of the virus and immunosuppressants for the treatment of the severe form of COVID-19, which often occurs in patients with chronic diseases and older persons.

Study · 2020

AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism

It was shown that AEDG peptide (Ala-Glu-Asp-Gly, Epitalon) regulates the function of the pineal gland, the retina, and the brain. AEDG peptide increases longevity in animals and decreases experimental cancerogenesis.

Study · 2017

Short Exogenous Peptides Regulate Expression of CLE, KNOX1, and GRF Family Genes in Nicotiana tabacum

Exogenous short biologically active peptides epitalon (Ala-Glu-Asp-Gly), bronchogen (Ala-Glu-Asp-Leu), and vilon (Lys-Glu) at concentrations 10 -7 -10 -9 M significantly influence growth, development, and differentiation of tobacco (Nicotiana tabacum) callus cultures.

animal · 2017

[ANTIINFLAMMATORY AND REGENERATIVE EFFECT OF PEPTIDE THERAPY IN THE MODEL OF OBSTRUCTIVE LUNG PATHOLOGY]

The effect of the tetrapeptide bronchogen on the structural and functional state of the bronchial epithelium and inflammatory activity in the lungs was studied in the chronic obstructive pulmonary disease (COPD) model, created in rats by a 60-day intermittent exposure to nitrogen dioxide.

animal · 2015

Modulating Effect of Peptide Therapy on the Morphofunctional State of Bronchial Epithelium in Rats with Obstructive Lung Pathology

On the model of chronic obstructive pulmonary disease, the effect of therapy with low-molecular-weight peptides on restructuring and functional activity of bronchial epithelium for restoring the immune and barrier function of the lungs and prevention of inflammatory process progression was studied.

Research use only — not for human consumption and not approved by the FDA. Nothing here is medical advice.